James Murrells FOP

US FOP prevalence higher than expected

The prevalence of fibrodysplasia ossificans progressiva (FOP) in the US is higher than previously believed, according to research published in the Orphanet Journal of Rare Diseases.

Anecdotal evidence supports further study of imatinib in children with FOP

Children treated for fibrodysplasia ossificans progressiva (FOP) with imatinib in an off-on-off-on (O4) regimen have fewer flare-ups, decreased swelling, and improved function when on versus off treatment, US researchers report.

Question 1	Image reproduces with permission from Kaplan FS, Xu M, Seemann P, et al. Hum Mutat 2009;30(3):379–90. © Copyright 2009. Published by John Wiley and Sons. Kaplan FS, Glaser DL, Shore EM, et al. Clin Rev Bone Miner Metab 2005; 3: 183–188.
Question 2	Tiwari V, Behera P, Sarawagi R, et al. Cureus 2018;10(7):e2955. © Copyright 2018. CC-BY 3.0. Pignolo RJ, Ramaswamy G, Fong JT, et al. Appl Clin Genet 2015;8:37–48.
Question 3	Dibello D, Di Carlo V, Colin G, et al. Ital J Pediatr 2020;46(1):78. Copyright © 2020, The Author(s). CC-BY 3.0.
Question 4	Pignolo RJ, Shore EM, Kaplan FS. Orphanet J Rare Dis 2011;6:80. Copyright © 2011. CC BY 2.0. Kitterman JA, Kantanie S, Rocke, Kaplan FS. Pediatrics 20\05;116:e654–e661.
Question 5	Image reproduces with permission from Gore AI, Spencer JP. Am Fam Physician 2004;69(4):865–72. © Copyright 2004. Published by American Academy of Family Physicians. Kitterman JA, Kantanie S, Rocke, Kaplan FS. Pediatrics 2005;116:e654–e661.
Question 6	Image reproduces with permission from Sun Y, Xia W, Jiang Y, et al. Calcif Tissue Int 2009;84(5):361–5. © Copyright 2009. Published by Springer Nature Switzerland AG.
Question 7	Image reproduces with permission from Kumagai K, Motomura K, Egashira M, et al. Skeletal Radiol 2008;37:563–567. © Copyright 2008. Published by Springer Nature Switzerland AG.
Question 8	Image reproduces with permission from Rashid U, Bari A, Maqsood A, et al. J Coll Physicians Surg Pak 2016;26(2):154–5. © Copyright 2016. Published by Journal of the College of Physicians & Surgeons Pakistan
Question 9	Image reproduces with permission from Butterworth ML, Marcoux JT. Juvenile Hallux Abductovalgus. In: Butterworth M., Marcoux J. (eds) The Pediatric Foot and Ankle. Springer, Cham, 2020. © Copyright 2020. Published by Springer Nature Switzerland AG.
Question 10	Image reproduces with permission from Kaplan FS, Xu M, Seemann P, et al. Hum Mutat 2009;30(3):379–90. © Copyright 2009. Published by John Wiley and Sons.

Author: James Murrells

US FOP prevalence higher than expected

Anecdotal evidence supports further study of imatinib in children with FOP

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